Not known Factual Statements About phenobarbital sodium drug class
Not known Factual Statements About phenobarbital sodium drug class
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pentobarbital will reduce the level or effect of naloxegol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Use of naloxegol with powerful CYP3A4 inducers will not be encouraged
Contraindicated (one)pentobarbital will lessen the level or effect of cariprazine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. CYP3A4 is accountable for the development and elimination of cariprazine's Lively metabolites.
pentobarbital will reduce the level or effect of buprenorphine subdermal implant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Carefully. Observe sufferers by now on buprenorphine subdermal implant who involve freshly-initiated remedy with CYP3A4 inducer for signs and symptoms of withdrawal.
Contraindicated (1)pentobarbital will lessen the level or effect of naloxegol by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Usage of naloxegol with powerful CYP3A4 inducers is not really recommended
pentobarbital will increase toxicity of buprenorphine, prolonged-acting injection by pharmacodynamic synergism. Modify Therapy/Keep track of Closely. Coadministration of buprenorphine and benzodiazepines or other CNS depressants increases chance of adverse reactions which include overdose, respiratory melancholy, and death. Cessation of benzodiazepines or other CNS depressants is most popular most often.
pentobarbital will decrease the extent or effect of fosphenytoin by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Keep an eye on.
pentobarbital will lower the level or effect of alosetron by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Unidentified.
pentobarbital will minimize the level or effect of almotriptan by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
Labor and supply: Hypnotic doses of these barbiturates never surface to noticeably impair uterine action in the course of labor. Comprehensive anesthetic doses of barbiturates lower the pressure and frequency of uterine contractions. Administration of sedative-hypnotic barbiturates to the mother in the course of labor may perhaps lead to respiratory depression while in the new child. Premature infants are specially liable to the depressant effects of barbiturates.
pentobarbital will reduce the level or effect of vincristine liposomal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Mysterious.
pentobarbital will lessen the extent or effect of bortezomib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.
Human info. Within a 29-year epidemiological examine of 9,136 sufferers who were being addressed on an click here anticonvulsant protocol that involved phenobarbital, final results indicated the next than typical incidence of hepatic carcinoma. Beforehand, A few of these people had been dealt with with thorotrast, a drug that is known to supply hepatic carcinomas. So, this research didn't give enough proof that phenobarbital sodium is carcinogenic in humans.
pentobarbital will minimize the extent or effect of elbasvir/grazoprevir by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. The therapeutic effect of elbasvir/grazoprevir can be diminished if coadministered with robust CYP3A inducers and is hence contraindicated.
pentobarbital will minimize the extent or effect of carbamazepine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.